2020 Feb;99(7):e19258.


2014 Jun;40(6):685-91. doi: 10.1016/j.ejso.2014.02.236. Methods: Systematic literature review and meta-analysis to compare PTR versus primary tumor intact (PTI). By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Median survival was calculated by using the Kaplan-Meier method.Of 21,405 colorectal cancer patients diagnosed with synchronous liver and/or lung metastases, 7386 were identified in the matched cohort. Background: To assess the impact of primary tumor resection (PTR) on survival and morbidity in incurable colorectal cancer. Moreover, recent papers have reported significantly better overall survival rates for patients undergoing PTR than patients who do … In addition, stratified analysis revealed that trimodality therapy was linked with the greatest therapeutic effect followed by addition of chemotherapy to pPTR.pPTR may offer some therapeutic benefits among carefully selected patients, and surgery-based multimodality therapy was associated with better survival.We use cookies to help provide and enhance our service and tailor content and ads.

Published by Elsevier Ltd. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. 2013 Jan;43(1):28-32. doi: 10.1093/jjco/hys175. ScienceDirect ® is a registered trademark of Elsevier B.V.Survival outcome of palliative primary tumor resection for colorectal cancer patients with synchronous liver and/or lung metastases: A retrospective cohort study in the SEER database by propensity score matching analysis© 2020 IJS Publishing Group Ltd.

Clipboard, Search History, and several other advanced features are temporarily unavailable. Unable to load your delegates due to an error Because MDSCs have been previously shown to increase in metastatic breast cancer and can suppress the antitumor function of T-cells, 15, 28 we investigated the effect of decreasing tumor burden by resection on the number of MDSCs, CD4, and CD8 cells in the spleen.



Whether palliative primary tumor resection is beneficial to metastatic colorectal cancer is unknown.Propensity score matching analysis of Surveillance, Epidemiology, and End Results Database.Explore the effect surgery interaction with other therapies on survival.Focus on common metastatic sites of colorectal cancer patients.There is a great matter of controversies whether some of these synchronous metastatic colorectal cancer patients can benefit from palliative primary tumor resection (pPTR) and there is still no reported randomized control trial to address this issue.Patients with microscopically proven metastatic colorectal cancer were identified within the SEER database (2010–2016). Primary tumor resection reverses the immunosuppressive effects of cancer progression.

doi: 10.1002/14651858.CD004078.pub2.Xiao W, Zou Y, Zheng S, Hu X, Liu P, Xie X, Yu P, Tang H, Xie X.Eur J Surg Oncol. Primary tumor resection could prevent tumor-related complications, such as intestinal obstruction, perforation, bleeding, or fistula [15, 17]. Primary tumor resection (PTR) is recommended for patients with unresectable stage IV colorectal cancer (CRC) who present with symptoms related to their primary tumor… Epub 2012 Oct 28.Petersen SH, Harling H, Kirkeby LT, Wille-Jørgensen P, Mocellin S.Cochrane Database Syst Rev. Palliative primary tumor resection (pPTR) may only be required for primary tumor–related adverse events, such as obstruction, perforation, or intractable hemorrhage. doi: 10.1097/MD.0000000000019258.de Mestier L, Neuzillet C, Pozet A, Desot E, Deguelte-Lardière S, Volet J, Karoui M, Kianmanesh R, Bonnetain F, Bouché O.Eur J Surg Oncol. Epub 2014 Feb 28.Cetin B, Kaplan MA, Berk V, Tufan G, Benekli M, Isikdogan A, Ozkan M, Coskun U, Buyukberber S.Jpn J Clin Oncol. Results: Seventy-seven studies were included, reporting on 159,991 participants (94,745 PTR; 65,246 PTI).

2020 Feb;99(7):e19258. These complications are associated with poor oncologic outcomes as well as perioperative morbidity and mortality.




Name must be less than 100 characters 2018 Oct;44(10):1504-1512. doi: 10.1016/j.ejso.2018.08.002. Spiral, Imperial College Digital Repository Epub 2018 Aug 11.Medicine (Baltimore).

In stratified analyses by primary site and patterns of distant metastases, those patients with pPTR had better prognosis. Springer This site needs JavaScript to work properly. Spiral, Imperial College Digital Repository Patients were propensity matched 1:1 into pPTR and non-surgery groups and among the matched cohort, the univariable and multivariable Cox proportional hazards regression models were performed to identify predictors of survival. Unable to load your collection due to an error Springer The median overall survival was 12.0 months, 22.0 months in the non-surgery, surgery groups, respectively (p < 0.001) and the corresponding median cancer-specific survival was 13.0 months, 22.0 months, respectively (p < 0.001). COVID-19 is an emerging, rapidly evolving situation. Multivariable Cox regression analysis demonstrated that surgery was independently associated with improved overall survival (hazard ratio, 0.531) as well as cancer-specific survival (hazard ratio, 0.516). doi: 10.1097/MD.0000000000019258. Medicine (Baltimore). 2012 Mar 14;2012(3):CD004078. On the other hand, some studies have demonstrated that surgical resection of the primary tumor in this patient population is not associated with a significant survival benefit, so it may be that the variation in study results is due to a wide distribution of treatment effects across different patient populations.

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